Wednesday, February 07, 2007

Anal Leakage Returns?

Wow, today the FDA approved a low-dose version of orlistat called Alli to be sold by GlaxoSmithKline PLC. The manufacturer claims the drug prevents absorption of 25% of fats consumed, or 150-200 calories. Whoopie! Go ahead, eat more! But beware (MSNBC):
When taken with meals, orlistat blocks the absorption of about one-quarter of any fat consumed. That fat — about 150 to 200 calories worth — is passed out of the body in stools, which can be loose as a result. About half of patients in trials experienced gastrointestinal side effects.
Anyone remember the alternate fat Olestra that stayed in your gut and caused, well, er, "anal leakage?" Look for Alli to be your ally in not only losing weight, but also treating constipation with interesting side effects (Medline Plus Drug Information):
The most common side effect of orlistat is changes in bowel movement (BM) habits. This generally occurs during the first weeks of treatment; however, it may continue throughout your use of orlistat. Tell your doctor if any of these symptoms are severe or do not go away:

  • oily, spotting BMs

  • gas with discharge

  • urgent need to have a BM

  • oily or fatty stools

  • an oily discharge

  • increased number of BMs

  • inability to control BMs

  • orange or brown color of a BM

  • stomach pain

  • irregular menstrual periods
How bad can this be? Just look at this hilarious post from Craig's List "Best of" Series regarding Pringles Fat-Free Potato Chips (warning, contains profanity). You might want to rethink how many pills you'll take!


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